Ryou Sagimiya has a rare condition called TSS, Transsexual Syndrome. While touring Tensei Academy Ryou meets Nagisa Minakami, another student with TSS and decides to enroll in the school. Ryou Sagimiya, who has a rare condition called "sexual change syndrome", admires Nagi Minakami, who he met on a school visit, and enrolls in Tensei Gakuen, where Nagi attends. A mixed (physical) crossing love comedy!